UCF 101
CAS No. 313649-08-0
UCF 101 ( —— )
产品货号. M27484 CAS No. 313649-08-0
UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥389 | 有现货 |
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5MG | ¥648 | 有现货 |
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10MG | ¥1126 | 有现货 |
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25MG | ¥2325 | 有现货 |
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50MG | ¥3686 | 有现货 |
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100MG | ¥5314 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称UCF 101
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.
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产品描述UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.(In Vitro):PC12 cells treated with 60 μM 6-OHDA for 24 h had significantly decreased cell viability compared to that of controls. A low concentration (2.5 μM) of UCF 101 decreased the apoptosis rate of the PD cell model, but a high concentration (≥10 μM) increased the apoptosis rate, compared to that of controls. 6-OHDA upregulated the expression of HtrA2, α-syn, CHOP, Grp78 and active caspase-3 and reduced the levels of TH and XIAP.(In Vivo):Administration of UCF 101 shortly before reperfusion reduced postischemic myocardial apoptosis in a dose-dependent fashion, with the maximal protective effect observed at a dose of 1.5 μmol/kg. This dose of UCF 101 (ie, 1.5 μmol/kg) was used in all subsequent experiments. To further establish that inhibition of Omi/HtrA2 protease activity led to significant inhibition of apoptosis, the effect of UCF 101 on DNA ladder formation, a hallmark of apoptotic cell death, was determined. 30 minutes of ischemia followed by 3 hours of reperfusion resulted in significant DNA fragmentation, which was significantly reduced by treatment with UCF 101 before reperfusion.UCF 101 reduced the level of ERS and apoptosis in vivo. The ratio of p-GSK3β (Tyr216 to Ser9) increased in PD rats.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体nAChR
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研究领域——
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适应症——
化学信息
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CAS Number313649-08-0
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分子量495.5
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分子式C27H17N3O5S
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纯度>98% (HPLC)
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溶解度——
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SMILES[O-][N+](c(cccc1)c1-c1ccc(C=C(C(N(c2ccccc2)C(N2c3ccccc3)=S)=O)C2=O)o1)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tadashi Yamamuro, et al. Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:85-94.
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